Research Agenda

Our overall aim is the identification, validation and translation of novel therapeutic targets for the treatment of chronic inflammatory skin diseases. 

Most projects focus on autoimmune skin blistering diseases, such as epidermolysis bullosa acquisita, bullous pemphigoid or pemphigus. In addition, we have established model systems for psoriasis, SLE and contact dermatitis

We believe that cooperations with other academic centers and industry are the key to contribute to the high medical need to develop effective and save treatment options for patients affected by chronic skin inflammatory diseases. Please fell free to contact us if you are interested in our reagents or if you would like to start a cooperation

Current Projects

Drug development for chronic inflammatory skin diseases

  • Libary-Screening 
  • Computer-based Screenings 
  • Validation of targets identified by hypothesis-driven research
  • Validation ot targets identified in genomic studies

Understanding loss of tolerance in AIBD

  • Cellular requirements for autoantibody production
  • Molecular requirements for autoantibody production

Understanding autoantibody-induced blistering in AIBD

  • Cellular requirements for blistering
  • Cytokines; e.g. IL-1, IL-6, TNF
  • Signaling molecules; eg PI3K beta, MAPK

Metabolomic inflammation

  • Impact of diet on inflammatory phenotypes

Allergy Research

Animal model systems

Patient cohorts

  • AIBD