Sven Marcel Stefan is a senior postdoctoral researcher at the University of Oslo (UiO) and the Oslo University Hospital (OUS) as well as an independent group leader at the LIED (University of Lübeck and University Medical Center Schleswig-Holstein).

He is a pharmacist by training and focused in his Master (2011–2012) and Doctoral Studies (2012–2017) in Pharmaceutical Biology and Chemistry the extraction, isolation, and structural characterization of natural compounds as well as the organic synthesis of bioactive agents and structure-activity relationships.

He conducted his research and teaching at the Universities of Sydney (2019–2020) and Oslo (since 2020) focusing bioinformatics, structural biology, and novel drug discovery approaches. Since 2022, he is also co-leader of the PANABC ( and PANSLC ( projects.

Sven Marcel Stefan’s research includes mapping of polypharmacological landscapes and complex bioactivity networks of multitarget agents. The differentiation between selectivity and promiscuity and the elucidation of structure-activity relationships is a major focus of his research. The development of innovative pattern-based computational models for virtual screening approaches to discover bioactive polypharmacological agents is emphasized. These agents are used for the exploration and potential exploitation of under-studied drug targets, particularly ATP-binding cassette (ABC) and solute carrier (SLC) transporters associated with neurodegenerative, malignant, and dermatological diseases. Sven Marcel Stefan has extensive expertise in the functional assessment of drug transporters and high-throughput screenings (HTS) of large analog compound libraries, as well as in hit-to-lead optimization via organic synthesis.

The PANABC project (DFG-funded):

Sven Marcel Stefan is a project leader of the PANABC project, which focuses the development of truly multitarget pan-ABC transporter modulators for the exploration of under-studied sibling transporters as potential pharmacological drug targets of the future. Two major aims are the establishment of an ABC transporter modulators database ( to strengthen data awareness as well as the functional characterization and exploitation of the so-called common structural and/or functional multitarget binding site amongst all/most ABC transport proteins. The PANABC project includes an international collaborative network providing a large-scale biological assessment platform, and it is supported by the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG; #504079349).