Antibody transfer model of bullous pemphigoid

The repeated injection of anti-murine NC15A BP180 (type XVII collagen) IgG in adult mice results in a clinical and immunopathological phenotype that mirrors the human disease. Deposits of IgG and C3 along the dermal-epidermal junction are found in perilesional skin biopsies, subepidermal blistering and a mixed inflammatory infiltrate are found in the upper dermis, and erosions and erythema develop preferentially around the snout, ears, and neck (Am J Pathol, 2014).

Subsequent analyses have shown that clinical disease depends on

The following therapeutic interventions led to disease improvement: