Research Agenda

Our overall aim is the identification, validation and translation of novel therapeutic targets for the treatment of chronic inflammatory skin diseases. 

Most projects focus on autoimmune skin blistering diseases, such as epidermolysis bullosa acquisita, bullous pemphigoid or pemphigus. In addition, we have established model systems for psoriasis, SLE and contact dermatitis

We believe that cooperations with other academic centers and industry are the key to contribute to the high medical need to develop effective and save treatment options for patients affected by chronic skin inflammatory diseases. Please fell free to contact us if you are interested in our reagents or if you would like to start a cooperation

Current Projects

Drug development for chronic inflammatory skin diseases
With a focus on pemphigus and pemphigpid dissease we persue different pathways for drug development for chronic inflammatory skin diseases. See our growing list of identified and validated drug targets for pemphigoid diseases.

Impact of genes and environment on complex traits
With the Research Training Froup "Genes, Environment and Inflammation" we investigate how genes and diet impact on complex phenotypes in the mouse.

Allergy Research
Here we focus on type IV allergic reactions to heparin.

Animal model systems
The following mouse model systems are established: