Type IV allergic reactions to heparins

We are conducting epidemiological research on heparin-induced, cutaneous adverese reaactions to heparin. In this context, the following main findings were made:

  • A low incidence of heparin-induced skin lesions in orthopedic surgery patients, Clin Exp Allergy. 2018
  • Nadroparin carries a potentially high risk of inducing cutaneous delayed-type hypersensitivity responses, Contact Dermatitis. 2017
  • A case report of tolerance of fondaparinux in immediate-type hypersensitivity to heparins, Am J Med. 2015
  • High incidence of heparin-induced allergic delayed-type hypersensitivity reactions in pregnancy, J Allergy Clin Immunol. 2013
  • Application, tolerance and safety of fondaparinux therapy in a German hospital: a prospective single-centre experience, Thromb Res. 2012
  • The risk for cross-reactions after a cutaneous delayed-type hypersensitivity reaction to heparin preparations is independent of their molecular weight: a systematic review, Contact Dermatitis. 2011
  • Low allergenic potential with fondaparinux: results of a prospective investigation (PDF), Mayo Clin Proc. 2010
  • Heparin-induced non-necrotizing skin lesions: rarely associated with heparin-induced thrombocytopenia (PDF), J Thromb Haemost. 2010
  • Incidence and causes of heparin-induced skin lesions (PDF), CMAJ. 2009
  • Tolerance of fondaparinux in patients with generalized contact dermatitis to heparin, J Eur Acad Dermatol Venereol. 2008
  • Molecular weight determines the frequency of delayed type hypersensitivity reactions to heparin and synthetic oligosaccharides, Thromb Haemost. 2005
    Note: The findings herein were based on a too small sample size and were prooven incorrect in later studies by others and us!

These findings are reviewed in:

Please contact us, if you need a reprint of any of the above articles (if not downloadable).