Pemphigoid diseases

"Conventional" treatments

• IVIG
• Steroids

Fc gamma receptor / immune complex - interactions

• SM101 (soluable Fc gamma receptor IIB, CD32)
• EndoS
• IdeS
• Fc gamma receptor 4

Cell signalling molecules

• PDE4
• PI3K β
• SYK
• p38 MAPK
• ERK1/2
• ROR α
• HSP90
• PI3K δ

Cytokines

• TNFα
• IL-10, protective
• Il1-Ra, protective
• GM-CSF
• IL-6, protective
• IL-1β

Cellular treatment

• Treg, protective

Complement

• C5a/C5aR1
• C1s
• C5aR2, protective

Repurposed medications

• Calcitriol
• Dimethyl fumarate

Lipid mediators

• LTB4

Others

• Nanoparticles
• Flightless I

Excluded targets

• TREM1
• C6
• CCL3
• MMP-8 and -14
• Caspase-1
• Mast cells, controvercial in the literature