Sophie Preuß completed her medical studies at the Ruprecht-Karls-University in Heidelberg, where she also carried out her doctoral research at the Department of Dermatology. 
Since April 2023, she has been working as a resident physician in the Department of Dermatology at the University Medical Center Schleswig-Holstein, Campus Lübeck (UKSH), and as a Clinician Scientist within the Clinician Scientist Program of the University of Lübeck. 
In her laboratory work, she currently investigates antibody-mediated mechanisms at the placenta in the pathogenesis of adverse pregnancy outcomes associated with pemphigoid gestationis. In addition, she conducts epidemiological and clinical studies.